Withdrawal symptoms can arise in breastfed infants when maternal administration of the opioid is stopped, or when breastfeeding is stopped.
Codeine has good antitussive action, Though lower than that of morphine at equivalent doses. It really is Utilized in choice to morphine, for the reason that Unwanted effects are rare at the standard antitussive dose of codeine.
Promethazine need to be utilised cautiously in persons with cardiovascular disease or with impairment of liver purpose.
Pregnancy Assessments: Diagnostic pregnancy exams depending on immunological reactions amongst HCG and anti-HCG may possibly cause false-damaging or Phony-optimistic interpretations.
Stimulation may very well be apparent, specifically in little ones and geriatric sufferers. Convulsions might not often happen. A paradoxical-form response has become documented in children getting solitary doses of seventy five mg to one hundred twenty five mg orally, characterized by hyperexcitability and nightmares.
The mixture of promethazine hydrochloride and codeine phosphate must be utilised with warning in pediatric individual six decades and older (see WARNINGS – Use in Pediatric Clients).
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate.
Phenothiazines are linked to dystonic reactions, particularly in pediatric people who have an acute ailment connected with dehydration. Paradoxical reactions, including dystonia, torticollis, tongue protrusion, hyperexcitability, and irregular actions have already been reported in sufferers subsequent just one administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Alternative if a paradoxical reaction takes place.
Labor or Shipping and delivery Opioids cross the placenta and should deliver respiratory despair and psycho-physiologic effects in neonates. An opioid antagonist, including naloxone, need to be obtainable for reversal of opioid-induced respiratory despair within the neonate.
Due to the opportunity for promethazine to reverse epinephrine’s vasopressor result, epinephrine really should not be utilized to take care of hypotension linked to promethazine overdose.
Promethazine is definitely an antihistamine which can be taken by mouth being an oral Option or tablet, rectally read more as being a suppository, or by injection. It can be employed for:
Pediatric patients should be supervised in order to avoid possible harm in bicycle Driving or in other dangerous things to do.
Postmarketing circumstances of respiratory melancholy, such as fatalities are noted with utilization of promethazine in pediatric patients.
Bone-marrow challenges and blood mobile generation. Promethazine HCl Oral Option really should not be Utilized in individuals with bone-marrow difficulties or employed with other medications that influence the bone marrow's manufacture of blood cells.